Repsox Small Molecule


IWP-4 Small Molecule



In stock
Small Molecules for Stem Cell Research

IWP-2 is an inhibitor of the Wnt pathway, specifically targeting membrane-bound O-acyltransferase porcupine (PORCN) with an IC50 of 27 nM. This inhibition, in turn, prevents Wnt activation, secretion, and signaling (Garcia-Reyes, et al.), which leads to decreased self-renewal of human embryonic stem cells (ESCs) (Kim, et al). IWP-2 has been an effective component within differentiation protocols of pluripotent stem cells (PSCs) into functional cardiomyocytes when combined with CHIR99021, IWP-4, Activin A, bFGF, and BMP4 (Lian, et al.). Additionally, IWP-2 shows promise in the differentiation of iPSCs into corneal epithelial cells (Mikhailova, et al.).

Size10 mg
Molecular NameIWP-2
Size10 mg
Alternative NamesIWP 2, Inhibitor of WNT Production-2
Chemical NameAcetamide, N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3- phenylthieno[3,2-d]pyrimidin-2-yl)thio]-
Chemical FormulaC22H18N4O2S3
Molecular Weight466.60
CAS Number686770-61-6
PurityGreater than 95% by NMR
Physical AppearanceWhite to off-white (Solid)
TargetPorcupine (PORCN)
Shelf-Life≥ 2 years (powder)
ShippingRoom Temperature
StorageStore at -20°C
Quality StatementThis product is for Research Use Only and is not intended for therapeutic or diagnostic use.
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