SANT-1 Small Molecule



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DAPT is a γ-secretase inhibitor (with IC50s of 115 and 200 nM for total Aβ and Aβ42, respectively) that can reduce Aβ40 and Aβ42 levels in human primary neuronal cells and brain extracts, DAPT also inhibits γ-secretase complex and indirectly inhibits Notch, a γ-secretase substrate (Dovey, et al). Its activity causes neural cells to commit to neuronal differentiation (Crawford et al). and has been shown to reduce colony-forming efficiency in mouse neural stem cells (Androutsellis-Theotokis et al). DAPT has also been shown to promote differentiation of pancreatic cells from human pluripotent stem cells (D’Amour et al).
Molecular NameGSI-IX; GSI IX, γ-Secretase Inhibitor IX, LY-374973
Chemical NameN-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
Chemical FormulaC₂₃H₂₆F₂N₂O₄
Molecular Weight432.46
CAS Number208255-80-5
PubChem ID5311272
Purity≥95% by NMR
Physical AppearanceWhite to off-white (Solid)
Targetγ-secretase; Autophagy
Shelf-Life≥ 2 years (Solid)
ShippingRoom Temperature
StorageStore at -20°C
Quality StatementThis product is for Research Use Only and is not intended for therapeutic or diagnostic use.
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