XAV939 Small Molecule


Thiazovivin Small Molecule


Compound E

In stock
Small Molecules for Stem Cell Research

Compound E is a potent γ-secretase inhibitor that specifically blocks β-amyloid-40 (IC50 of 0.24), β-amyloid-42 (IC50 of 0.37), and cleavage of the Notch domain (IC50 of 0.32). Compound E has been shown to promote the differentiation of embryonic stem cells (ESCs) to primitive neural precursors in addition to generating a self-renewing progenitor neuroepithelia stem cell population (Li, et al.) when combined with CHIR99021, SB431542, and hLIF. Forebrain GABA interneurons have also been derived from human pluripotent stem cells (PSCs) through the utilization of Compound E (Liu, et al.); additionally, it has shown promising effects in Alzheimer’s disease models using iPSC-derived neurons (Yagi, et al.).

Size10 mg
Molecular NameCompound E
Size10 mg
Alternative NamesXXI, Compound E (secretase inhibitor), DuPont E, C-E, γ-secretase inhibitor XXI, Gammasecretase inhibitor XXI, gamma inhibitor
Chemical NameBenzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-
Chemical FormulaC27H24F2N4O3
Molecular Weight490.50
CAS Number209986-17-4
PurityGreater than 95% by LCMS
Physical AppearanceWhite to off-white (Solid)
Shelf-Life≥ 2 years
StorageStore at -20°C

Compound E Technical Data Sheet

Compound E SDS

Brochure: Small Molecules for Stem Cell Research

FAQs: General Guide for Small Molecules

References and Publications

Li, et al. 2011. Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. PNAS. 108(20): 8299-304.

Liu, et al. 2013. Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nature Protocols. 8: 1670-1679.

Yagi, et al. 2011. Modeling familial Alzheimer’s disease with induced pluripotent stem cells. Human Molecular Genetics. 20(23): 4530-4539.

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